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赵吉喆.炎症-血管痉挛性心绞痛的治疗新靶点[J].内科急危重症杂志,2024,30(6):487-492
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| DOI：10.11768/nkjwzzzz.20240602 |
| 中文关键词: 血管痉挛性心绞痛 炎症 难治性血管痉挛性心绞痛 抗炎疗法 |
| 英文关键词: |
| 基金项目:国家自然科学基金（82330010；82241034；82370507），湖北省顶尖人才计划及同济医院优秀青年基金滚动资助（24-2KYC13057-04）部分资助 |
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| 摘要点击次数: 494 |
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| 中文摘要: |
| 摘要：血管痉挛性心绞痛（VSA）是由冠状动脉痉挛引发的心绞痛，严重影响患者健康。尽管传统治疗方法如硝酸甘油和钙通道阻滞剂在大多数患者中有效，但对于难治性和复发性VSA患者效果不佳，且无法改善患者预后。近期研究表明，心肌炎症在VSA的发病机制中起着关键作用，炎症相关的生物标志物和影像学检查在VSA的诊断中展现出重要价值，为临床实践提供了新的视角。此外，抗炎和免疫调节治疗逐渐受到关注，显示出改善难治性和复发性VSA患者预后的潜力。未来的研究应集中于炎症细胞和因子在VSA中的动态变化，并准确评估心脏及冠状动脉的炎症状态，以期实现更个性化的治疗策略。总之，针对炎症的治疗为VSA患者带来了新的希望，是VSA治疗的新靶点。 |
| 英文摘要: |
| Abstract Vasospastic angina (VSA), characterized by coronary artery spasm, significantly affects patient health. While conventional treatments like nitroglycerin and calcium channel blockers benefit most of patients with VSA, they often prove ineffective for refractory VSA, leading to poor outcomes. Recent studies underscore the pivotal role of inflammation in VSA pathogenesis, particularly via allergic reactions, myocarditis, and inflammation of adjacent tissues. Inflammatory biomarkers and advanced imaging techniques have emerged as valuable tools for diagnosing VSA, offering fresh perspectives for clinical practice. Additionally, anti-inflammatory and immune-modulating therapies are gaining traction for their potential to enhance outcomes in refractory VSA patients. Future research should focus on the dynamic alterations of inflammatory cells and mediators in VSA, as well as the precise evaluation of the inflammatory status in the heart and coronary arteries, to develop more personalized treatment approaches. Overall, inflammation-targeted therapies present promising new avenues for VSA management, with the potential for significant advancements in clinical applications. |
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