潘婧.血清GDF-15及sST2可诊断急性一氧化碳中毒患者发生心肌损伤[J].内科急危重症杂志,2024,30(6):524-527
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| DOI：10.11768/nkjwzzzz.20240608 |
| 中文关键词: 血清生长分化因子-15 可溶性生长刺激表达基因2 急性一氧化碳中毒 心肌损伤 |
| 英文关键词: |
| 基金项目:孝感市科学技术局资助项目（XGKJ2020010005） |
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| 中文摘要: |
| 摘要：目的：探究血清生长分化因子-15（GDF-15）、可溶性生长刺激表达基因2（sST2）对急性一氧化碳中毒（ACOP）患者心肌损伤的诊断价值。方法：选取82例ACOP住院患者为研究对象，根据患者入院后3h肌钙蛋白I（cTnI）水平分为心肌损伤组（33例）和无心肌损伤组（49例），采集所有患者入院时的空腹静脉血，用酶联免疫吸附法（ELISA）检测2组血清GDF-15及sST2水平；全自动生化分析仪检测心肌酶 [肌酸激酶（CK）、肌酸激酶同工酶（CK-MB）]水平，比较组间差异。采用Pearson法分析血清GDF-15及sST2与心肌酶水平的相关性，受试者工作特征（ROC）曲线分析血清GDF-15及sST2对ACOP患者发生心肌损伤的诊断价值；Logistic回归分析ACOP患者发生心肌损伤的影响因素。结果：心肌损伤组有吸烟史患者的比例及血清GDF-15、sST2、CK、CK-MB水平显著高于无心肌损伤组（P均＜0.05）；Pearson相关分析显示，ACOP患者血清GDF-15、sST2水平与CK、CK-MB水平呈正相关（P均＜0.05）；血清GDF-15、sST2水平单独诊断及其两者联合诊断ACOP患者发生心肌损伤的曲线下面积（AUC）分别为0.854、0.885、0.945。Logistic分析显示，血清GDF-15、sST2、CK、CK-MB水平及有吸烟史是ACOP患者发生心肌损伤的影响因素（P均＜0.05）。结论：血清GDF-15、sST2水平在ACOP心肌损伤患者中明显升高，且为ACOP患者并发心肌损伤的独立影响因素，二者联合检测对ACOP患者发生心肌损伤的诊断价值较高。 |
| 英文摘要: |
| Abstract Objective: To investigate the diagnostic value of serum growth differentiation factor-15 (GDF-15) and soluble growth stimulating gene 2 (sST2) for myocardial injury in patients with acute carbon monoxide poisoning (ACOP). Methods: Totally, 82 hospitalized patients with ACOP were selected as the research subjects, and were divided into myocardial injury group (33 cases) and non-myocardial injury group (49 cases) based on their cTnl levels at 3 h after admission. The fasting venous blood was collected from all patients upon admission, and enzyme-linked immunosorbent assay (ELISA) was used to detect serum GDF-15 and sST2 levels in two groups. The fully automated biochemical analyzer was used to detect the levels of myocardial enzymes [creatine kinase (CK), creatine kinase isoenzyme (CK-MB)] and the differences between groups were compared. The Pearson method was used to analyze the correlation between serum GDF-15, sST2 and myocardial enzyme levels. Receiver operating characteristic (ROC) curve was used to analyze serum GDF-15 and sST2 for the diagnostic value of myocardial injury in ACOP patients. Logistic regression analysis was used to evaluate the influencing factors of myocardial injury in ACOP patients. Results: The proportion of patients with a history of smoking and the levels of serum GDF-15, sST2, CK, and CK-MB in the myocardial injury group were significantly higher than those in the non-myocardial injury group (all P<0.05). Pearson correlation analysis showed that serum GDF-15 and sST2 levels in ACOP patients were positively correlated with CK and CK-MB levels (all P<0.05). The areas under the curve (AUC) of serum GDF-15, sST2 levels, and their combined diagnosis of ACOP patients with myocardial injury were 0.854, 0.885, and 0.945, respectively. Logistic analysis showed that serum GDF-15, SST2, CK, CK-MB levels, and smoking history were influencing factors for myocardial injury in ACOP patients (P<0.05). Conclusion: Serum GDF-15 and sST2 levels are significantly elevated in patients with ACOP myocardial injury, and are independent influencing factors for the occurrence of myocardial injury in ACOP patients. The combined detection of the two has high diagnostic value for the occurrence of myocardial injury in ACOP patients. |
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