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张春瑞.血清S100β、Aβ及NSE联合检测可提高急性脑梗死脑侧支循环建立的预测效能[J].内科急危重症杂志,2024,30(6):542-544
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| DOI：10.11768/nkjwzzzz.20240612 |
| 中文关键词: 急性脑梗死 脑侧支循环 钙结合蛋白β β-淀粉样蛋白 神经元特异性烯醇化 |
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| 中文摘要: |
| 摘要 目的：探讨血清钙结合蛋白β（S100β）、β-淀粉样蛋白（Aβ）及神经元特异性烯醇化酶（NSE）水平联合检测在预测急性脑梗死（ACI）患者脑侧支循环建立中的价值。方法：选取132例ACI患者为疾病组，另选取同期150例健康体检者为对照组，疾病组患者的侧支循环建立情况用脑血管数字减影血管造影（DSA）进行判断，根据DSA检查结果，将0级患者归为无侧支循环建立组（51例），1~4级患者归为侧支循环建立组（81例）。2组血清S100β、Aβ及NSE水平用酶联免疫吸附法进行测定，并采用受试者工作特征（ROC）曲线分析各项指标单项及联合检测对侧支循环建立的预测价值。结果：疾病组血清S100β、Aβ及NSE水平高于对照组（P均＜0.05）；DSA检查结果显示，132例患者中有81例（61.36%）患者侧支循环建立，侧支循环建立组血清S100β、Aβ及NSE水平低于无侧支循环建立组（P均＜0.05）；ROC结果显示，血清S100β、Aβ及NSE水平联合检测判断ACI患者侧支循环建立的灵敏度及曲线下面积（AUC）高于三者单项检测（P均＜0.05），但特异性与三者单项检测比较，差异无统计学意义（P均＞0.05）。结论：ACI患者血清S100β、Aβ及NSE水平较健康人群更高，且与脑侧支循环的建立有关，三者联合检测对ACI患者脑侧支循环建立预测效能更高。 |
| 英文摘要: |
| Abstract Objective: To explore the value of combined detection of serum calcium binding protein β (S100β), β-amyloid protein (Aβ) and neuron specific enolase (NSE) levels in predicting the establishment of cerebral collateral circulation in patients with acute cerebral infarction (ACI). Methods: A total of 132 patients with ACI were selected as the disease group, and 150 people receiving healthy physical examination were selected as the control group. The establishment of collateral circulation in the disease group was judged by digital subtraction angiography (DSA). According to the DSA examination results, the grade 0 patients were classified as non-collateral circulation establishment group (51 cases), and the grade 1-4 patients were classified as collateral circulation establishment group (81 cases). The levels of serum S100β, Aβ and NSE in the two groups were measured by enzyme-linked immunosorbent assay, and the receiver operating characteristic (ROC) curve was used to analyze the predictive value of single and combined detection of each index for the establishment of collateral circulation. Results: The levels of serum S100β, Aβ and NSE in the disease group were higher than those in the control group (all P< 0.05). The DSA results showed that 81 out of 132 patients (61.36%) had collateral circulation establishment, and the levels of serum S100β, Aβ and NSE in the collateral circulation establishment group were lower than those in the non-collateral circulation establishment group (all P< 0.05). The ROC results showed that the sensitivity and area under the curve (AUC) of the combined detection of serum S100β, Aβ and NSE levels in determining the establishment of collateral circulation in ACI patients were higher than those of the three separate tests (all P< 0.05), but there was no significant difference in specificity between combined detection and three separate tests (all P> 0.05). Conclusion: The levels of serum S100β, Aβ and NSE in ACI patients are higher than those in healthy people, and they are related to the establishment of cerebral collateral circulation. The combined detection of the three is more effective in predicting the establishment of cerebral collateral circulation in ACI patients. |
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