王媛媛.铁死亡引发心房颤动的作用机制及治疗策略[J].内科急危重症杂志,2024,30(6):557-560
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| DOI：10.11768/nkjwzzzz.20240616 |
| 中文关键词: 铁死亡 心房颤动 氧化应激 靶向治疗 |
| 英文关键词: |
| 基金项目:科技部重点研发项目（2020YFC2008904） |
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| 摘要点击次数: 66 |
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| 中文摘要: |
| 摘要 心房颤动（AF）由于其高发病率和由其产生的严重并发症，如血栓形成和心力衰竭，给社会带来了严重的医疗负担。目前对于AF的治疗有限。铁死亡是一种铁依赖的程序性细胞死亡方式，其特征是铁代谢紊乱、脂质过氧化和活性氧（ROS）聚积，与多种疾病有关。新证据表明，铁死亡可以作为减少AF发生的治疗靶点，已在动物模型中得到验证。本文探讨铁死亡在AF治疗中的潜在作用，为开发新疗法提供新思路。 |
| 英文摘要: |
| Abstract Atrial fibrillation (AF), due to its high incidence and severe complications such as thrombosis and heart failure, poses a significant healthcare burden on society. Currently, the treatment options for AF are limited. Ferroptosis, an iron-dependent programmed cell death characterized by iron metabolism disorder, lipid peroxidation, and reactive oxygen species (ROS) accumulation, has been linked to various diseases. Emerging evidence suggests that ferroptosis can serve as a therapeutic target to reduce the occurrence of AF, which has been validated in animal models. This article explores the potential role of ferroptosis in AF treatment, providing new ideas for the development of novel therapies. |
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