早期肠内营养有利于改善脓毒性休克的临床症状

杨基.早期肠内营养有利于改善脓毒性休克的临床症状[J].内科急危重症杂志,2025,31(1):45-48

DOI：10.11768/nkjwzzzz20250107

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作者	单位	E-mail
杨基	山西医科大学第三医院（山西白求恩医院山西医学科学院同济山西医院)	1943730288@ qq.com

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中文摘要:

摘要目的：比较早期肠内营养（EEN）与延迟肠内营养（DEN）对脓毒性休克患者的临床疗效。方法：收集79例脓毒性休克患者，分为EEN组（<48 h肠内营养）31例和DEN组48例。比较2组患者肝素结合蛋白、降钙素原（PCT）、肝肾功能、凝血功能、序贯器官衰竭评分（SOFA）、白细胞计数（WBC）、中性粒细胞计数（NEUT）、机械通气时间、ICU住院天数、28 d死亡率等。结果：2组SOFA评分差值、PCT差值、总胆红素（TBIL）差值、ICU住院天数、28 d存活率、入院第7、14天的WBC、NEUT比较，差异有统计学意义（P均<0.05）。结论：早期肠内营养对脓毒性休克患者的临床症状改善更明显，可提高生存率。

英文摘要:

Abstract Objective: To compare the clinical efficacy of early enteral nutrition (EEN) versus delayed enteral nutrition (DEN) in patients with septic shock. Methods: A total of 79 patients with septic shock were collected and divided into the EEN group (enteral nutrition within <48h) consisting of 31 cases and the DEN group with 48 cases. The two groups were compared in terms of heparin-binding protein, procalcitonin (PCT), liver and kidney function, coagulation function, sequential organ failure assessment (SOFA) score, white blood cell (WBC) count, neutrophil (NEUT) count, duration of mechanical ventilation, length of stay in the ICU, and 28-day mortality. Results: Statistically significant differences were observed between the two groups in the SOFA score, PCT, total bilirubin, length of stay in the ICU, 28-day survival rate, and WBC count and NEUT count on days 7 and 14 after admission (all P <0.05). Conclusion: EEN significantly improves the clinical symptoms of patients with septic shock and can increase survival rates.