急性缺血性脑卒中患者血清成纤维细胞生长因子21、C1q 肿瘤坏死因子相关蛋白 12水平及其预后价值

于海艳.急性缺血性脑卒中患者血清成纤维细胞生长因子21、C1q 肿瘤坏死因子相关蛋白 12水平及其预后价值[J].内科急危重症杂志,2025,31(1):62-64

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DOI：10.11768/nkjwzzzz20250111

中文关键词: 急性缺血性脑卒中成纤维细胞生长因子21 C1q 肿瘤坏死因子相关蛋白 12 预后

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作者	单位	E-mail
于海艳	山东省青岛市城阳区人民医院	ojcljb@163.com

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中文摘要:

摘要目的：探讨急性缺血性脑卒中（AIS）患者血清成纤维细胞生长因子21（FGF21）、C1q 肿瘤坏死因子相关蛋白 12（CTRP12）水平及其预后价值。方法：收集108例AIS患者临床资料，根据美国国立卫生研究院卒中量表（NIHSS）评分将AIS患者分为轻度组36例、中度组38例及重度组34例；持续治疗14d后，随访6个月，分为预后良好组65例和预后不良组43例。选取同期体检的健康志愿者98例为对照组。采用酶联免疫吸附法测定血清FGF21、CTRP12水平。结果：与对照组比较，AIS组患者FGF21、CTRP12的表达水平显著降低（P均＜0.05）。重度组显著低于中度组和轻度组，中度组显著低于轻度组（P均＜0.05）。Pearson分析显示，AIS患者FGF21与CTRP12表达呈正相关（r=0.338，P＜0.05）。预后良好组血清FGF21、CTRP12的水平显著高于预后不良组（P均＜0.05）。Logistic回归分析显示，血清FGF21、CTRP12水平为AIS发生的影响因素（P均＜0.05）。ROC曲线分析显示，血清FGF21、CTRP12二者联合预测AIS预后不良的AUC高于单独预测。结论：FGF21、CTRP12在AIS患者血清中呈低表达，且与AIS患者预后有关。

英文摘要:

Abstract Objective: To investigate the serum levels of fibroblast growth factor 21 (FGF21) and tumor necrosis factor related protein 12 (serum complement C1q/tumor necrosis factor related protein 12, CTRP12) in patients with acute ischemic stroke (AIS) and their prognostic value. Methods: The clinical data of 108 AIS patients were collected. AIS patients were divided into mild group (36 cases), moderate group (38 cases) and severe group (34 cases) according to NIHSS score. After 14 days of continuous treatment, AIS patients were followed up for 6 months, and were divided into 65 patients with good prognosis and 43 patients with poor prognosis. Totally, 98 healthy volunteers in our hospital during the same period were selected as the control group. The levels of serum FGF21 and CTRP12 were measured by enzyme linked immunosorbent assay (ELISA). Results: The serum levels of FGF21 and CTRP12 in AIS group were obviously lower than in the control group (P<0.05). The serum levels of FGF21 and CTRP12 in severe group were obviously lower than those in moderate group and mild group, and those in moderate group were obviously lower than those in mild group (P< 0.05). Pearson analysis showed that there was a positive correlation between the serum levels of FGF21 and CTRP12 in AIS patients (r= 0.338, P <0.05). The serum levels of FGF21 and CTRP12 in patients with good prognosis were obviously higher than those in patients with poor prognosis (P< 0.05). Logistic regression analysis showed that the serum levels of FGF21 and CTRP12 were the influencing factors for AIS occurrence (P< 0.05). ROC curve analysis showed that the AUC value predicted by the combination of the two methods for poor prognosis of AIS was greater than that predicted by FGF21 or CTRP12 alone (Z =18.804, P< 0.001; Z= 4.574, P= 0.032). Conclusion: FGF21 and CTRP12 are low expressed in the serum of AIS patients, and they are related to the prognosis of AIS patients and may be potential biomarkers for the prognosis evaluation of AIS.