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申东北.热射病相关肝损伤机制及治疗研究进展[J].内科急危重症杂志,2025,31(1):83-86
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| DOI：10.11768/nkjwzzzz20250116 |
| 中文关键词: 热射病 肝损伤 发病机制 治疗策略 |
| 英文关键词: |
| 基金项目:云南省科技厅科技计划项目(202201AY070001-283);云南省科技厅科技计划项目(202101AU070087) |
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| 中文摘要: |
| 摘要 热射病（HS）是一种危及生命的全身性疾病，其特征是核心体温升高超过40℃并随后出现多器官功能障碍综合征。肝脏是热射病发生发展中较易受到损害的器官之一，也是该病致死的直接原因。研究发现，除了热细胞毒性、凝血功能障碍、全身性炎症反应综合征等全身性因素的综合作用外，肝细胞过度焦亡、kupffer细胞功能障碍、热休克蛋白表达异常等因素也参与其中。本文拟对热射病相关肝损伤的重要发病机制及治疗研究进展作一综述，以期为干预疾病的发生、发展和探索疾病潜在的治疗靶点提供参考。 |
| 英文摘要: |
| Abstract Heat stroke (HS) is a life threatening systemic illness characterized by an increase in core body temperature of more than 40°C followed by the development of multiple organ dysfunction syndrome. The liver is one of the organs that are more susceptible to damage in the occurrence and development of heat stroke, and it is also the direct cause of death from the disease. Studies have found that in addition to the combined effects of systemic factors such as heat cytotoxicity, coagulation dysfunction, and systemic inflammatory response syndrome, hepatocyte hyperpyroptosis, kupffer cell dysfunction, and abnormal expression of heat shock protein are also involved. This article aims to review the important pathogenesis and treatment progress of heatstroke-related liver injury, in order to provide a reference for intervening in the occurrence, development and exploration of potential therapeutic targets of the disease. |
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