王玲.IgG4相关性疾病与过敏的关系[J].内科急危重症杂志,2025,31(2):1-5
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| DOI：10.11768/nkjwzzzz20250201 |
| 中文关键词: IgG4相关性疾病 过敏 临床表现 发病机制 诊断与治疗 |
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| 中文摘要: |
| 摘要 IgG4相关性疾病(IgG4-RD)是一种罕见的自身免疫性疾病，其发病机制目前见解纷呈，但仍谜题待解，这向该病的临床管理抛出了巨大的难题，给患者和社会带来了沉重的医疗和经济负担。近年来，在临床工作和众多研究中发现部分IgG4-RD患者存在过敏史和“过敏样”实验室表现，这为IgG4-RD发病机制和治疗策略的研究提供了新的思路。本文分别从临床症状、发病机制、诊断与治疗3个方面来综述IgG4-RD和过敏之间的关系，旨在为IgG4-RD进一步的机制研究提供资料和依据。 |
| 英文摘要: |
| Abstract IgG4-related disease (IgG4-RD) is a rare autoimmune disorder with an unclear pathogenesis. Currently, there are diverse opinions on it, but the question remains unanswered, posing significant challenges to clinical management of the disease and imposing a heavy medical and economic burden on patients and society. In recent years, clinical observations and numerous studies have identified that some IgG4-RD patients have a history of allergy and "allergic-like" laboratory findings, providing novel insights into the pathogenesis and therapeutic strategies of IgG4-RD. This article reviews the association between IgG4-RD and allergy from the perspectives of clinical symptoms, pathogenesis, diagnosis and treatment, aiming to provide information and a basis for further mechanism research on IgG4-RD. |
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