|
刘晖.血清内皮细胞特异性分子-1及人帕金森病蛋白2对急性脑梗死患者并发血管性痴呆有预测价值[J].内科急危重症杂志,2025,31(3):235-238
|
| DOI：10.11768/nkjwzzzz20250308 |
| 中文关键词: 急性脑梗死 血管性痴呆 内皮细胞特异性分子-1 人帕金森病蛋白2 |
| 英文关键词: |
| 基金项目: |
|
| 摘要点击次数: 56 |
| 全文下载次数: 65 |
| 中文摘要: |
| 摘要 目的：探讨血清内皮细胞特异性分子-1（ESM-1）及人帕金森病蛋白2（PARK2）水平与急性脑梗死（ACI）患者并发血管性痴呆（VD）的相关性。 方法：选取384例ACI患者，根据是否并发VD将其分为无VD组（236例）和VD组（148例），根据《临床痴呆评定量表》将VD组分为轻度痴呆（50例）、中度痴呆（59例）、重度痴呆（39例）。比较各组血清ESM-1及PARK2水平，采用Pearson/Spearman法分析VD痴呆程度与ESM-1、PARK2水平的相关性，并探讨ACI患者发生VD的影响因素；采用受试者工作特征（ROC）曲线下面积（AUC）评价血清ESM-1、PARK2水平对ACI并发VD的预测价值。 结果：VD组血清ESM-1、PARK2水平低于无VD组（P均＜0.05）。Logistic回归分析显示，年龄、文化程度、病变范围、ESM-1及PARK2是并发VD的影响因素（P均＜0.05）。VD组轻度、中度、重度痴呆患者的血清ESM-1、PARK2水平依次降低（P均＜0.05）。VD组患者血清中ESM-1与PARK2呈正相关（r=0.552，P＜0.05），血清ESM-1、PARK2水平与VD痴呆程度呈负相关（r=-0.456、-0.518，P均＜0.05）。血清ESM-1、PARK2预测ACI并发VD的截断值分别为1.07μg/L、4.04ng/mL，血清ESM-1联合PARK2预测并发VD的AUC优于二者单独检测。 结论：血清ESM-1、PARK2水平变化与ACI并发VD密切相关，二者联合检测对ACI并发VD有较好预测价值。 |
| 英文摘要: |
| Abstract Objective: To investigate the relationship between serum endothelial cell specific molecule-1 (ESM-1) and human Parkinson's disease protein 2 (PARK2) levels and concurrent vascular dementia (VD) in patients with acute cerebral infarction (ACI). Method: Totally, 384 patients with ACI were selected and divided into a non VD group based on whether they had concurrent VD (236 cases) and VD group (148 cases), according to the Clinical Dementia Rating Scale. The VD group was divided into mild dementia (50 cases), moderate dementia (59 cases), and severe dementia (39 cases). The levels of serum ESM-1 and PARK2 were compared in each group, the correlation between the degree of VD and the levels of ESM-1 and PARK2 was analyzed using Pearson/Pearman method, and the influencing factors of VD in ACI patients were evaluated. The predictive value of serum ESM-I and PARK2 levels for VD in ACI was evaluated using the area under the receiver operating characteristic (ROC) curve (AUC). Results: The levels of serum ESM-1 and PARK2 in the VD group were lower than those in the non VD group (both P< 0.05). Logistic regression analysis showed that age, educational level, lesion range, ESM-1, and PARK2 were all influencing factors for the development of VD (P< 0.05). The serum levels of ESM-1 and PARK2 in patients with mild, moderate, and severe dementia in the VD group decreased sequentially (all P< 0.05). The levels of ESM-1 and PARK2 in the serum of VD patients were positively correlated (r= 0.552, P <0.05), while the levels of ESM-I and PARK2 in the serum were negatively correlated with the degree of VD (r=-0.456, -0.518, both P< 0.05). The cutoff values for predicting concurrent VD in ACI using serum ESM-1 and PARK2 were 1.07μg/L and 4.04ng/mL, respectively. The AUC of predicting concurrent VD using serum ESM-1 combined with PARK2 was better than that of detecting either alone. Conclusion: The changes in serum ESM-1 and PARK2 levels are closely related to the occurrence of VD in ACI, and the combination of the two has good predictive value for VD in ACI. |
|
|
|
|
