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代杰.血清死亡关联蛋白激酶1和谷胱甘肽过氧化酶1水平与急性缺血性脑卒中患者病情及预后有关[J].内科急危重症杂志,2025,31(3):248-251
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| DOI：10.11768/nkjwzzzz20250311 |
| 中文关键词: 急性缺血性脑卒中 死亡关联蛋白激酶1 谷胱甘肽过氧化酶1 预后 |
| 英文关键词: |
| 基金项目:河北省2020年度医学科学研究课题计划（20200336） |
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| 摘要点击次数: 55 |
| 全文下载次数: 72 |
| 中文摘要: |
| 摘要 目的：探讨急性缺血性脑卒中（AIS）患者血清死亡关联蛋白激酶1（DAPK1）和谷胱甘肽过氧化酶1（GPX1）水平与病情、预后的关系。方法：选取收治的118例AIS患者为观察组，另选取118例同期健康体检者为对照组。根据美国国立卫生研究院卒中量表（NIHSS）评分将观察组分为轻度组（30例）、中度组（48例）和重度组（40例），再根据改良Rankin（mRS）评分量表将观察组分为预后良好组（90例）和预后不良组（28例）。采用Logistic回归分析AIS患者预后不良的影响因素。采用受试者工作特征（ROC）曲线分析血清DAPK1、GPX1水平对AIS患者不良预后的评估价值。结果：观察组血清DAPK1水平高于对照组，GPX1水平低于对照组（P＜0.05）。轻度、中度、重度组的血清DAPK1水平依次递增，血清GPX1水平依次递减，且各组之间差异显著（P均＜0.05）。与预后良好组比较，预后不良组血清DAPK1水平升高，血清GPX1水平降低（P均＜0.05）。血清DAPK1为AIS预后的危险因素，GPX1为其保护因素（P均＜0.05）。血清DAPK1、GPX1单项及二者联合预测AIS预后不良的曲线下面积（AUC）分别为0.853、0.874、0.960，二者联合的预测价值优于其单独预测（Z二者联合-DAPK1=2.535，P=0.011；Z二者联合-DAPK1=2.005，P=0.045）。结论：血清DAPK1、GPX1水平对AIS预后呈现出良好的评估价值。 |
| 英文摘要: |
| Abstract Objective: To explore the relationship between the expression of serum death associated protein kinase 1 (DAPK1) and glutathione peroxidase 1 (GPX1) in patients with acute ischemic stroke and their condition and prognosis. Methods: In total, 118 patients with acute ischemic stroke were included as the study subjects (observation group), and 118 healthy individuals in the same period were selected as the control group. The National Institutes of Health Stroke Scale (NIHSS) was used to evaluate the severity of the condition, which was divided into mild group (30 cases), moderate group (48 cases), and severe group (40 cases). The modified Rankin Scale (mRS) was used to assess the prognosis, which was divided into good prognosis group (90 cases) and poor prognosis group (28 cases). Receiver operating characteristic (ROC) curve analysis of DAPK1 and GPX1 was used to evaluate the poor prognosis of patients with acute ischemic stroke, and logistic regression analysis to evaluate the influencing factors of poor prognosis in patients with acute ischemic stroke. Results: The serum DAPK1 level in observation group was obviously higher than that in control group, and the serum GPX1 level was obviously lower in observation group than that in control group (P<0.05). The serum DAPK1 level in mild, moderate, and severe groups increased in sequence, and the serum GPX1 level decreased in sequence (P< 0.05). The serum DAPK1 level in poor prognosis group was obviously higher than that in good prognosis group, and the serum GPX1 level was obviously lower in poor prognosis group than that in good prognosis group (P< 0.05). Area under the curve (AUC) of serum DAPK1, GPX1, and their combination for predicting poor prognosis in acute ischemic stroke was 0.853, 0.874, and 0.960, respectively. The combined predictive value of the two was better than that of serum DAPK1, GPX1 alone (Zcombination-DAPK1= 2.535, P= 0.011; Zcombination-GPX1=2.005, P= 0.045). Serum DAPK1 was a risk factor for prognosis of acute ischemic stroke, and GPX1 was a protective factor (P< 0.05). Conclusion: The expression levels of serum DAPK1 and GPX1 show good evaluation value for the prognosis of acute ischemic stroke. |
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