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姜汛.昼夜节律紊乱与2型糖尿病并发症发生风险及其机制研究进展[J].内科急危重症杂志,2025,31(4):295-303
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| DOI：10.11768/nkjwzzzz20250402 |
| 中文关键词: 昼夜节律紊乱 糖尿病并发症 心血管病变 糖尿病肾病 糖尿病视网膜病变 生物钟基因 |
| 英文关键词: |
| 基金项目:国家自然科学基金项目（82370835） |
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| 摘要点击次数: 13 |
| 全文下载次数: 16 |
| 中文摘要: |
| 摘要 现代生活方式改变导致的昼夜节律紊乱现象日益凸显，包括轮班工作、睡眠时间不足、睡眠节律紊乱等行为模式已成为心血管和代谢性疾病的重要危险因素。研究表明，这种昼夜节律紊乱不仅参与2型糖尿病的发病过程，更可能通过复杂的分子机制增加其心血管病变、肾病和视网膜病变等并发症的发生风险及严重程度。本文从流行病学证据到分子机制层面对昼夜节律紊乱与2型糖尿病及其并发症进行深入分析，总结新进研究进展，旨在为糖尿病及其并发症的防治提供新思路。 |
| 英文摘要: |
| Abstract Changes in modern lifestyles have made circadian-rhythm disruption increasingly prominent. Behavioral patterns such as shift work, insufficient sleep duration, and irregular sleep timing have emerged as major public-health challenges. Evidence indicates that these disruptions not only contribute to the onset of T2DM but, via complex molecular mechanisms, may also heighten the risk and severity of complications—including cardiovascular disease, nephropathy, and retinopathy. This review offers an in-depth analysis of circadian-rhythm disruption in relation to T2DM and its complications-spanning epidemiological data through molecular insights and summarizes recent advances with the goal of providing fresh perspectives for the prevention and management of diabetes and its sequelae. |
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