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申超娜.磁共振血管成像参数对急性脑梗死患者血管狭窄有诊断价值[J].内科急危重症杂志,2026,32(1):34-38
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| DOI：10.11768/nkjwzzzz20260108 |
| 中文关键词: 急性脑梗死 磁共振血管成像 血管狭窄 血管新生 侧支循环 |
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| 摘要点击次数: 59 |
| 全文下载次数: 61 |
| 中文摘要: |
| 摘要 目的：探讨磁共振血管成像（MRA）参数与对急性脑梗死（ACI）患者血管狭窄的诊断价值。方法：选取ACI患者158例作为研究组，纳入同期158例健康体检者作为对照组。统计2组MRA参数（血管狭窄评分、侧支循环充盈评分）、血管新生因子[血管内皮生长因子（VEGF）、基质金属蛋白酶-9（MMP-9）、血管内皮生长因子受体2（VEGFR2）]，Pearson相关性检验分析MRA参数与血管新生因子相关性，偏相关性分析MRA参数与ACI患者血管狭窄相关性，绘制受试者工作特征（ROC）曲线分析MRA参数对血管狭窄的诊断效能。结果：研究组侧支循环充盈评分、血管狭窄评分及VEGF、VEGFR2水平低于对照组，阳性患者低于阴性患者（P均＜0.05）；研究组MMP-9水平高于对照组，阳性患者高于阴性患者（P均＜0.05）；血管狭窄评分、侧支循环充盈评分与VEGF、VEGFR2呈正相关，与MMP-9呈负相关（P均＜0.05）；偏相关性显示，血管狭窄评分、侧支循环充盈评分与ACI患者血管狭窄呈负相关（P均＜0.05）；ROC曲线显示血管狭窄评分、侧支循环充盈评分联合诊断ACI患者血管狭窄价值优于单一诊断价值（曲线下面积：0.926 vs 0.773、0.833）。结论：ACI血管狭窄患者MRA参数与血管新生因子密切相关，对血管狭窄的诊断效能高。 |
| 英文摘要: |
| Abstract Objective: To explore the correlation and diagnostic value of magnetic resonance angiography (MRA)-related parameters with angiogenesis in patients with acute cerebral infarction (ACI) and vascular stenosis.Methods: A total of 158 ACI patients were selected as the study group, and 158 healthy subjects in the same period were included as the control group. MRA-related parameters (vascular stenosis score, collateral circulation filling score), angiogenesis factor \[vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), VEGF receptor 2 (VEGFR2)\] of the two groups were analyzed. Pearson correlation coefficient was used to analyze the correlation between MRA-related parameters and angiogenesis factor. Partial correlation analysis was performed to analyze the correlation between MRA-related parameters and vascular stenosis in ACI patients, and the receiver operating characteristic (ROC) curve and area under the ROC curve (AUC) were plotted to analyze the diagnostic value of MRA related parameters. Results: The collateral circulation filling score, vascular stenosis score, the content of VEGF and VEGFR2 in the study group were lower than those in the control group, and those in the positive patients were lower than in the negative patients ( all P<0.05). The content of MMP-9 in the study group was higher than that in the control group, and that in the positive patients was higher than in the negative patients (P< 0.05). Vascular stenosis score and collateral circulation filling score were positively correlated with VEGF and VEGFR2, and negatively correlated with MMP-9 (allP< 0.05). Partial correlation showed that vascular stenosis score and collateral circulation filling score were negatively correlated with vascular stenosis in ACI patients ( all P< 0.05 ). The ROC curve showed that the combined diagnostic value of vascular stenosis score and collateral circulation filling score in the diagnosis of vascular stenosis in ACI patients was better than that of single diagnostic value (area under the curve: 0.926 vs 0.773,0.833). Conclusion: MRA-related parameters are closely related to angiogenesis factors in patients with ACI vascular stenosis, and the determination of MRA-related parameters has high diagnostic efficacy. |
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