|
莫文仲.脓毒症所致急性肾损伤过程中的免疫调节机制研究进展[J].内科急危重症杂志,2026,32(1):86-91
|
| DOI：10.11768/nkjwzzzz20260119 |
| 中文关键词: 脓毒症 急性肾损伤 免疫调节 炎症级联反应 免疫细胞 |
| 英文关键词: |
| 基金项目: |
|
| 摘要点击次数: 70 |
| 全文下载次数: 58 |
| 中文摘要: |
| 摘要 脓毒症是一种全身性炎症反应综合征，常导致多器官功能障碍。脓毒症诱导的急性肾损伤（SAKI）是其最常见的并发症之一，会较大增加患者死亡率。SAKI的发病机制复杂，主要涉及免疫炎症反应、血流动力学变化、微血管功能障碍、氧化应激和代谢重组等方面。先天免疫系统中的中性粒细胞、单核/巨噬细胞、树突细胞和自然杀伤细胞在响应病原体感染时发挥关键作用。适应性免疫系统中的T细胞和B细胞通过调节炎症反应和免疫平衡，影响肾功能恢复和预后。此外，神经免疫调节也在SAKI进展过程中发挥一定的功能。本文对SAKI发生发展中的免疫调节机制作一综述，旨在为SAKI的治疗提供新的思路和方法。 |
| 英文摘要: |
| Abstract Sepsis is a systemic inflammatory response syndrome that often leads to multiple organ dysfunction, with acute kidney injury (AKI) being one of its common complications, referred to as sepsis induced acute kidney injury (SAKI). The pathophysiological mechanisms of SAKI are complex, primarily involving immune inflammatory responses, hemodynamic changes, microvascular dysfunction, oxidative stress, and metabolic reprogramming. Innate immune cells, such as neutrophils, monocytes/macrophages, dendritic cells, and natural killer cells, play key roles in responding to pathogen infections but can exacerbate inflammation and cause kidney damage when overactivated. Adaptive immune cells, including T cells and B cells, influence kidney function recovery and prognosis by modulating inflammatory responses and immune balance. This review summarizes the known immune mechanisms involved in the development and progression of SAKI, aiming to provide new insights and approaches for the treatment of SAKI. |
|
|
|
|
