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麻雅娴.EB病毒相关噬血细胞综合征的诊疗进展[J].内科急危重症杂志,2026,32(2):110-115
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| DOI：10.11768/nkjwzzzz20260202 |
| 中文关键词: Epstein Barr病毒 噬血细胞综合征 诊断 治疗 |
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| 摘要点击次数: 121 |
| 全文下载次数: 145 |
| 中文摘要: |
| 摘要 噬血细胞综合征（HLH），是一种由免疫调节功能异常引发的过度炎症反应综合征，其发病机制与诊疗策略一直是临床关注的重点。EB(Epstein-Barr)病毒相关HLH（EBV-HLH）是感染相关HLH中最常见的类型，具有起病急、进展快、预后差的特点，临床常表现为持续发热，并伴有血细胞减少、肝脾肿大、肝功能损害等多系统受累表现。因此，早期识别、精准诊断与及时干预对改善患者预后至关重要。本文围绕EB病毒与HLH的关系、EBV-HLH的诊断方法以及治疗策略展开综述，以期为临床实践提供参考。 |
| 英文摘要: |
| Abstract Hemophagocytic lymphohistiocytosis (HLH) is an excessive inflammatory response syndrome caused by immune dysregulation, whose pathogenesis and management strategies have long been key clinical concerns. Epstein-Barr virus-associated HLH (EBV-HLH) is the most common type of infection-related HLH, characterized by acute onset, rapid progression, and poor prognosis. It typically presents with persistent fever accompanied by multi-system involvement such as cytopenia, hepatosplenomegaly, and liver dysfunction. Therefore, early recognition, precise diagnosis, and timely intervention are crucial for improving patient prognosis. This review focuses on the relationship between Epstein-Barr virus and HLH, the diagnostic approaches for EBV-HLH, and current treatment strategies, aiming to provide insights for clinical practice. |
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