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陆奕然.脓毒症相关性淋巴细胞减少症研究进展[J].内科急危重症杂志,2026,32(2):182-187
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| DOI：10.11768/nkjwzzzz20260216 |
| 中文关键词: 脓毒症 淋巴细胞减少症 免疫抑制 预后 |
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| 摘要点击次数: 114 |
| 全文下载次数: 142 |
| 中文摘要: |
| 摘要 脓毒症是一种由感染导致器官功能障碍的免疫反应失调，免疫抑制在脓毒症的发生发展中扮演着重要角色。其中，淋巴细胞减少作为免疫抑制的表现之一，与脓毒症疾病进展、多器官功能障碍、二次感染、不良预后等密切相关。本文就脓毒症相关淋巴细胞减少症定义、流行病学及其对脓毒症的影响和治疗进展等方面进行综述，以期为以淋巴细胞为靶点深入理解脓毒症免疫抑制和开发个体化治疗提供参考，改善脓毒症患者预后。 |
| 英文摘要: |
| Abstract Sepsis is a dysregulated host response to infection that leads to lifethreatening organ dysfunction, in which immunosuppression plays a critical role in the onset and progression of the disease. Lymphopenia, a key manifestation of immunosuppression in sepsis, is closely associated with disease progression, multiple organ dysfunction, secondary infections and poor prognosis. This review summarizes the definition and epidemiology of sepsisassociated lymphopenia, as well as its impact on sepsis and recent advances in therapeutic approaches, aiming to provide a reference for targeting lymphocytes to deepen the understanding of immunosuppression in sepsis and to facilitate the development of individualized therapies, thereby improving the prognosis of patients with sepsis. |
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