食管鳞癌患者癌性贫血的危险因素分析
Analysis of risk factors of cancerous anemia in patients with esophageal squamous cell carcinoma

王海瑞.食管鳞癌患者癌性贫血的危险因素分析[J].内科急危重症杂志,2021,27(1):23-25

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DOI：10.11768/nkjwzzzz20210107

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基金项目:河南省高等学校重点科研项目(No:21A320006);洛阳市科技计划医疗卫生项目(No:1813003A);河南科技大学创新基金项目(No:CXJJ-2019-KJ02)

作者	单位	E-mail
王海瑞	河南科技大学临床医学院	cbply2908@126.com

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中文摘要:

目的：探讨食管鳞癌患者癌性贫血的危险因素。方法：回顾性分析180例食管鳞癌患者的临床资料，分为贫血组与非贫血组。分析贫血与食管鳞癌患者临床病理特征之间的相关性。分析2组贫血相关指标的差异及食管鳞癌的贫血类型。用Logistic回归方法分析影响贫血的因素。结果：180例食管鳞癌患者中，78例存在不同程度的贫血。贫血的发生与血清白蛋白水平、TNM分期、分化程度及有无淋巴结转移具有相关性（均P＜0.05），与年龄、性别、肿瘤部位无相关性（均P>0.05）。78例贫血患者中，大细胞性贫血占26.92%，正常细胞性贫血占17.95%，小细胞性贫血占55.13%。血清白蛋白水平、TNM分期、淋巴结转移情况与贫血的发生密切相关（均P＜0.05），是贫血发生的独立预后因素。结论：食管鳞癌患者癌性贫血是由多种因素共同作用的结果，在治疗中要注意预防贫血的发生，提高患者的生活质量。

英文摘要:

Objective: To explore the risk factors of cancerous anemia in patients with esophageal squamous cell carcinoma. Methods: 180 patients with esophageal squamous cell carcinoma diagnosed in our hospital from August 2017 to December 2019 were selected, and their clinical data were analyzed. T-test was used to analyze the correlation between anemia and clinicopathological characteristics of patients with esophageal squamous cell carcinoma. The changes of anemia indexes and the types of anemia in esophageal squamous cell carcinoma between the two groups were analyzed by χ2 test. The influencing factors of anemia were analyzed by Logistic regression. Results: Totally 78 patients with esophageal squamous cell carcinoma had different degrees of anemia. Statistical analysis showed that the occurrence of anemia was correlated with serum albumin level, TNM stage, degree of differentiation and lymph node metastasis (P< 0 05), but not with age, sex and tumor location (P> 0 05). According to the analysis of the types of anemia, it was found that large cell anemia accounted for 26.92%, normal cell anemia accounted for 17.95%, and small cell anemia accounted for 55.13%. Serum albumin level, TNM stage and lymph node metastasis were closely related to the occurrence of anemia, and they were independent prognostic factors of anemia. Conclusion: Cancerous anemia in patients with esophageal squamous cell carcinoma results from many factors, so in the treatment, we should pay attention to prevent the occurrence of anemia and improve the quality of life of the patients.