噻托溴铵吸入剂联合小剂量阿奇霉素治疗稳定期慢性阻塞性肺病患者的疗效
Efficacy of tiotropium bromide inhalation combined with low-dose azithromycin in the treatment of patients with stable chronic obstructive pulmonary disease

张丽萍.噻托溴铵吸入剂联合小剂量阿奇霉素治疗稳定期慢性阻塞性肺病患者的疗效[J].内科急危重症杂志,2021,27(1):33-35

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DOI：10.11768/nkjwzzzz20210110

中文关键词: 噻托溴铵小剂量阿奇霉素稳定期慢性阻塞性肺疾病 疗效炎症因子

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作者	单位	E-mail
张丽萍	北京市海淀医院	ping8760@sina.com

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中文摘要:

目的：探讨噻托溴铵吸入剂联合小剂量阿奇霉素治疗稳定期慢性阻塞性肺疾病（COPD）患者的疗效及对炎症因子的影响。方法：选择稳定期COPD患者86例，随机分为对照组与观察组，各43例。对照组在常规治疗基础上给予噻托溴铵吸入剂治疗；观察组在对照组基础上联合小剂量阿奇霉素治疗。疗程均为6个月。比较2组疗效，治疗前后肺功能、6min步行距离(6MWD)和圣乔治呼吸问卷(SGRQ)评分及血白细胞介素（IL）-6、IL-8、肿瘤坏死因子（TNF）-α水平。结果：观察组总有效率高于对照组（90.70% vs 69.77%,P<0.05）。治疗后，2组FEV1、FEV1%和FEV1/FVC均升高（均P<0.05）；且观察组高于对照组（均P<0.05）。治疗后，2组6MWD均增大， SGRQ评分均降低（均P<0.05）；且观察组6MWD高于对照组， SGRQ评分低于对照组（均P<0.05）。治疗后，2组血清IL-6、IL-8和TNF-α水平降低（均P<0.05）；且观察组低于对照组（均P<0.05）。结论：噻托溴铵吸入剂联合小剂量阿奇霉素治疗对稳定期COPD患者疗效良好，可降低患者血IL-6、IL-8和TNF-α水平。

英文摘要:

Objective: To investigate the efficacy of tiotropium bromide inhalation combined with low-dose azithromycin in the treatment of patients with stable chronic obstructive pulmonary disease (COPD) and its influence on inflammatory factors. Methods: Eighty-six patients with stable COPD were selected and randomly divided into control group and observation group, with 43 cases in each group. The control group was treated with tiotropium bromide inhalation on the basis of conventional treatment; the observation group was treated with low-dose azithromycin on the basis of the control group. The course of treatment was 6 months. The efficacy of the two groups was compared before and after treatment, and lung function, 6-min walking distance (6MWD), St. George's Respiratory Questionnaire (SGRQ) scores, and blood interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-α levels before and after treatment were analyzed. Results: The total effective rate in the observation group was significantly higher than that in the control group (90.70% vs 69.77%, P<0.05). After treatment, FEV1, FEV1% and FEV1/FVC increased in the two groups (all P<0.05); FEV1, FEV1% and FEV1/FVC in the observation group after treatment were significantly higher than in the control group (P<0.05). After treatment, the 6MWD in the two groups increased, and the SGRQ score decreased (P<0.05); and 6MWD was significantly higher, and the SGRQ score was significantly lower in the observation group than in the control group (P<0.05). After treatment, the serum levels of IL-6, IL-8 and TNF-α decreased in the two groups (P<0.05); and those in the observation were significantly lower than those in the control group (P<0.05). Conclusion: Tiotropium bromide inhalation combined with low-dose azithromycin therapy has a satisfactory efficacy in the treatment of patients with stable COPD, and can reduce the blood levels of IL-6, IL-8 and TNF-α.