程扬帆.肌萎缩侧索硬化患者疼痛症状的研究进展[J].内科急危重症杂志,2022,28(3):177-181
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| DOI：10.11768/nkjwzzzz20220301 |
| 中文关键词: 肌萎缩侧索硬化 疼痛 机制 治疗 |
| 英文关键词: |
| 基金项目:国家自然科学基金面上项目（No：81871000）;四川省科技计划项目（No：2022ZDZX0023） |
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| 中文摘要: |
| 肌萎缩侧索硬化(ALS)是一种累及上、下运动神经元的致死性神经系统变性疾病，以进行性肌肉萎缩、无力的运动症状为主要表现。近年来，ALS患者的认知、精神症状、疼痛等非运动症状也受到越来越多的关注，其中疼痛作为ALS常见的非运动症状，严重影响患者的生活质量。本文通过总结既往文献，系统阐述了ALS患者出现疼痛的流行病学、临床特征、可能的发病机制和管理方法，强调了早期识别并标准化评估ALS疼痛的重要性。 |
| 英文摘要: |
| Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease with fatal outcome, involving upper and lower motor neurons, mainly presenting progressive loss of limb strength and atrophy. Recently, more studies focused on the non-motor symptoms including cognitive impairment, psychiatric symptoms and pain in patients with ALS. Pain, as a common but largely neglected symptom of ALS, affects the quality of life of patients seriously. In this paper, we summarized previous studies and systematically described the epidemiology, clinical features, possible pathogenesis and management of pain in ALS patients, and emphasized the importance of early identification and standardized assessment of pain in ALS patients. |
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